Molecular Imaging

ISBN: 978-1-60795-005-9




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July 2010
1,380 pages
Casebound / 8 1/2" x 11"
ISBN 978-1-60795-005-9
Print $189.00

Ralph Weissleder, MD, PhD

Professor of Radiology and Systems Biology

Harvard Medical School
Director, Center for Systems Biology

Massachusetts General Hospital

Boston, Massachusetts

Brian D. Ross, PhD
Professor of Radiology and Biological Chemistry
Co-Director Center for Molecular Imaging
University of Michigan Medical School
Ann Arbor, Michigan
Alnawaz Rehemtulla, PhD
Ruth Tuttle Freeman Research Professor, Department of Radiation Oncology and Radiology
Co-Director Center for Molecular Imaging
University of Michigan Medical School
Ann Arbor, Michigan
Sanjiv S. Gambhir, MD, PhD
Virginia & D.K. Ludwig Professor of Radiology and Bioengineering
Director, Molecular Imaging Program at Stanford (MIPS)
Director, Canary Center for Cancer Early Detection at Stanford
Chief, Division of Nuclear Medicine
Stanford University School of Medicine
Stanford, California

Read a review of the book:
We have corrected Errata in Chapter 28 and made the revised chapter available for free access.
Over the last decade, the field of molecular imaging of living subjects has evolved considerably and has seen spectacular advances in chemistry, engineering, and biomedical applications. In a relatively short period of time, comprehensive molecular imaging centers have been established in the US, Europe, and Asia and are increasingly integrated into basic sciences and translational networks. New investigators, collaborators, and students drawn into this multidisciplinary field have often expressed the desire and need for an authoritative textbook. This textbook was designed precisely to fill this need.

Given the multidisciplinary nature of the field, the book is broken into six different sections. Part 1 (Molecular Imaging Technologies) summarizes the different macro-, meso-, and microscopic imaging technologies currently available.

Part 2 (Chemistry of Molecular Imaging) is dedicated to reviewing chemical approaches to imaging probe designs for different types of imaging technologies. This section also contains chapters on the emerging field of nanomaterials, chemical biology, and probe design as well as signal amplification strategies.

Part 3 (Molecular Imaging in Cell and Molecular Biology) contains chapters dedicated to protein engineering, vectors, and pathways.

Part 4 (Applications of Molecular Imaging) summarizes the above advances in different clinical disease entities.

Part 5 (Molecular Imaging in Drug Evaluation) is dedicated to imaging in drug development.

Part 6 provides chapters on computation, bioinformatics, and modeling.

Key Features
  • The most authoritative and effective resource available in the field
  • Concepts illustrated with figures and molecular-imaging examples
  • First book to provide all the pieces for molecular imaging as a field including all the various modalities and biomedical applications
  • First book to cover the chemistry of imaging agent development as well as all the imaging instrumentation strategies

Table of Contents
Part I: Molecular Imaging Technologies

1    General Principles of Molecular Imaging
2    Imaging of Structure and Function with PET/CT
3    PET/MRI
5    Principles of Micro X-ray Computed Tomography
6    Small Animal SPECT, SPECT/CT, and SPECT/MRI
7    Instrumentation and Methods to Combine Small Animal PET with Other Imaging Modalities
8    Functional Imaging Using Bioluminescent Imaging
9    Optical Multimodality Technologies
10    Fiber Optic Fluorescence Imaging
11    Fluorescence Tomography
12    Endomicroscopy
13    Intravital Microscopy
14    Diffuse Optical Tomography and Spectroscopy
15    Ultrasound
16    Molecular Photoacoustic Tomography
17    Optical Projection Tomography
18    Potential Roles for Retrospective Registration in Molecular Imaging

Part II: Chemistry of Molecular Imaging

19    Chemistry of Molecular Imaging: An Overview
20    Radiochemistry of PET
21    Radiochemistry of SPECT: Examples OF 99MTc and 111In Complexes
22    Nanochemistry for Molecular Imaging
23    Newer Bioconjugation Methods
24    Targeted Antibodies and Peptides
25    Hyperpolarized 13C Magnetic Resonance Imaging – Principles and Applications
26    Magnetic Resonance Imaging Agents
27    Optical Imaging Agents
28    Ultrasound Contrast Agents
29    Multimodality Agents
30    “Click Chemistry”: Applications to Molecular Imaging
31    The “One-Bead-One-Compound” Combinatorial Approach to Identifying Molecular Imaging Probes
32    Chemical Biology Approaches to Molecular Imaging
33    Theranostics:  Agents for Diagnosis and Therapy
34    Magnetic Nanoparticles
35    Fluorocarbon Agents for Quantitative Multimodal Molecular Imaging and Targeted Therapeutics
36    Aptamers for Molecular Imaging
37    Nonclinical Product Developmental Strategies, Safety Considerations, and Toxicity Profiles of Medical Imaging and Radiopharmaceutical Products

Part III: Molecular Imaging in Cell & Molecular Biology

38    Overview of Molecular and Cell Biology
39    Systems Biology
40    Protein Engineering for Molecular Imaging
41    Phage Display for Imaging Agent Development
42    Molecular Imaging of Gene Therapy
43    Developing Diagnostic and Therapeutic Viral Vectors
44    Cell Voyeurism Using Magnetic Resonance Imaging
45    Tumor Vasculature
46    Imaging Hypoxia
47    Molecular Imaging of Protein-Protein Interactions
48    Fluorescence Readouts of Biochemistry in Live Cells and Organisms
49    Imaging of Signaling Pathways

Part IV: Applications of Molecular Imaging

50    Molecular and Functional Imaging of the Tumor Microenvironment
51    Novel MR and PET Imaging in the RT Planning and Assessment of Response of Malignant Gliomas 
52    PET Diagnosis and Response Monitoring in Oncology
53    Magnetic Resonance Spectroscopy Treatment Response and Detection
54    Diffusion MRI: A Biomarker for Early Cancer Treatment Response Assessment

55    Myocardial Metabolism
56    Congestive Heart Failure
57    Molecular Imaging of Atherosclerosis
58    Thrombosis and Embolism
59    Molecular Imaging of Stem Cells in Myocardial Infarction

60    Central Nervous System Molecular Imaging
61    Neuroreceptor Imaging: Applications, Advances, and Limitations
62    PET and SPET Imaging of Neurodegenerative Diseases Autoimmune/Immunology:
63    Molecular Imaging of Autoimmune Diseases
64    Rheumatoid Arthritis
65    Autoimmune Diabetes
66    Imaging in Asthma

Part V: Molecular Imaging in Drug Evaluation

67    Molecular and Functional Imaging in Drug Development
68    PET Imaging Cancer Clinical Trials
69    MR Imaging in Clinical Trials
70    Imaging of Gene Therapy: Basis and Clinical Trials

Part VI: Other

71    Visualization
72    Quantification of Radiotracer Uptake into Tissue
73    Mining Genomic Data for Molecular Imaging Targets
74    Pharmacokinetic Modeling
75    Cost-Effectiveness Analysis/Economics of Probe Development
76    Regulatory and Reimbursement Process for Imaging Agents and Devices